Soft-Tissue Necrosis Induced by Extravasated Cancer Chemotherapeutic Agents2, 3
- 1 June 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 66 (6) , 1129-1136
- https://doi.org/10.1093/jnci/66.6.1129
Abstract
The inadvertent extravasation of anticancer drugs in clinical use may result in the development of indolent lesions at the site of injection. Investigation of this phenomenon in Hartley guinea pigs showed that the pathogenesis was based on direct tissue toxicity and not on sensitization. The risk of a serious reaction appeared to be related to the localization of the injurious agent within the dermis rather than at the subcutaneous site.Keywords
This publication has 3 references indexed in Scilit:
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- Recall Injury from AdriamycinAnnals of Internal Medicine, 1975
- Adriamycin Activating a Recall Phenomenon After Radiation TherapyAnnals of Internal Medicine, 1974