AUTORADIOGRAPHIC DISTRIBUTION STUDIES OF INJECTED 32P-LABELLED POLYDIETHYLSTILBOESTROL PHOSPHATE

Publisher Website
Google Scholar
Abstract
The autoradiographic distribution pattern of intravenously injected 32P-polydiethylstilbestrol phosphate (32P-PSP), in which the diethylstilbestrol molecules are linked by 32P-phosphate bonds, has been studied in mice. In accordance with previous findings with a PSP-preparation labelled with 14C in the diethylstilbestrol molecules an accumulation was seen in tissues rich in reticuloendothelial cells which are a probable depot for the macromolecule. Contrary to 14C-PSP no specific uptake of 32P was observed in tissues presumed to be targets for estrogens. This indicates that only the monomolecular diethylstilbestrol and not the polymer shows affinity to the target sites.

This publication has 0 references indexed in Scilit: