Substrate Utilization by Stimulated Nerve

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Abstract
The CO2 production from C14-labeled substrates by resting and stimulated frog sciatic nerve was measured. The following substrates gave no extra CO2 production during nerve stimulation: glucose, acetate-1-C14, pyruvate-2-C14 lactate-1-C14, and glycine-2-C14. Extra CO2 during stimulation was given by the following: glutamate-2-C14, alanine-1-C14 and glycine-1-C14. Glutamate gave the greatest amount of extra CO2 and giycine the least, and with alanine the total number of stimuli and the amt. of extra CO2 were roughly equivalent.

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