The Interaction between Adriamycin and Radiation in a Solid Murine Tumor

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Abstract
Combinations of single and multiple doses of adriamycin and radiation were studied in EMT-6/Ro tumor-bearing BALB/cKa mice. The response to these chemotherapy-radiotherapy treatments was determined using a tumor growth delay assay. The single-dose interaction between adriamycin and radiation was assessed using an isoeffect analysis and was additive for both a 2 and 120 interval between agents when changes in tumor size were accounted for. When a single dose, 2 equal doses, or multiple daily doses of adriamycin (all to the same total dose) were combined with a course of ten 200 rad fractions given in 12 days, the resultant tumor growth delays also were in keeping with an additive response between the 2 treatment modalities. In combination with fractionated radiotherapy, a large single dose of adriamycin was more effective than concurrent small daily adriamycin exposures.

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