Stable rightward shifts of the oxyhemoglobin dissocation curve induced by encapsulation of inositol hexaphosphate in red blood cells using electroporation
- 26 November 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 275 (1-2) , 117-120
- https://doi.org/10.1016/0014-5793(90)81453-u
Abstract
Rightward shifts of 50–100% of the P 50 values in the oxygen dissociation curve of intracellular hemoglobin are obtained after encapsulation of inositol hexaphosphate in mouse and dog red blood cells (RBC) by electroporation. Life spans of mouse RBC‐myo‐inositol hexaphosphate in circulation are unchanged from the normal RBC values.Keywords
This publication has 10 references indexed in Scilit:
- Long-term physiological effects of enhanced O2 release by inositol hexaphosphate-loaded erythrocytes.Proceedings of the National Academy of Sciences, 1987
- Biotinylated erythrocytes: in vivo survival and in vitro recoveryBlood, 1987
- Physiological effects of high-P50 erythrocyte transfusion on pigletsJournal of Applied Physiology, 1985
- Improved Oxygen Delivery to Tissues and Iron Chelator Transport through the Use of Lysed and Resealed Red Blood Cells: A New Perspective on Cooley's Anemia TherapyaAnnals of the New York Academy of Sciences, 1985
- Incorporation of inositol hexaphosphate into intact red blood cellsThe Science of Nature, 1979
- Improvement of the red blood cell O2 release capacity by lipid vesicle-mediated incorporation of inositol hexaphosphateAnnals of Hematology, 1979
- Survival of sucrose-loaded erythrocytes in the circulationNature, 1978
- Reciprocal interaction of hemoglobin with oxygen and protons. The influence of allosteric polyanionsBiochemistry, 1977
- Enzyme loading of electrically homogeneous human red blood cell ghosts prepared by dielectric breakdownBiochimica et Biophysica Acta (BBA) - Biomembranes, 1976
- Permeability changes induced by electric impulses in vesicular membranesThe Journal of Membrane Biology, 1972