Insulin reverses effects of starvation on the activity of pyruvate dehydrogenase kinase in cultured hepatocytes
- 15 August 1987
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 246 (1) , 233-236
- https://doi.org/10.1042/bj2460233
Abstract
In tissue culture of hepatocytes, insulin (0.1-1 munits/ml for 4 h) reversed completely the effects of starvation of rats to decrease the activity of pyruvate dehydrogenase (PDH) complex and to increase the activities of PDH kinase and PDH kinase activator protein. It had no effect in hepatocytes from fed rats. Significant effects of insulin were detected with 0.01 munit/ml after 4 h, and in 1-2 h with 1 munit/ml.This publication has 20 references indexed in Scilit:
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