DNCB — Reactivity and Skin Irritation

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To the Editor: Sensitization tests with 2,4-dinitrochlorobenzene (DNCB) are used routinely as a measure for cell-mediated immune reactivity. In an article in the Journal Johnson and his co-workers1 presented some evidence, however, that may lead to the assumption that failure to respond to DNCB may be caused by a defective inflammatory response rather than by a faulty cellular immune recognition or responsiveness. They observed that 12 out of 13 patients with cancer who had negative reactions to DNCB failed to react to a primary irritant (10 per cent croton oil) as well.In an attempt to evaluate Johnson's findings we . . .

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