SYNTHESIS OF SYMMETRICAL AND UNSYMMETRICAL AMIDOPHOSPHITES

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Abstract
A method is proposed for one-pot synthesis of either symmetrical or unsymmetrical diester amidophosphites, developed on the basis of tris-(N,N-dimethyl)-amide/or tris-(N,N-diethyl)-amide/of phosphorous acid, activated by iodine, as a new phosphorylating reagent. Nine thiophosphate, phosphite and phosphite monoester and diester derivatives of 1-O-stearoyl-ethane-2-ol, cholesterol, β-sitosterol and R,S-α-tocopherol have been synthesized under mild conditions (20–75°C) and in high final yields (83--98%).