Evidence for human T cell lymphoma-leukemia virus infection of family members of human T cell lymphoma-leukemia virus positive T cell leukemia-lymphoma patients.
Open Access
- 1 January 1983
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 157 (1) , 248-258
- https://doi.org/10.1084/jem.157.1.248
Abstract
Sera of family members of patients from the United States, the Caribbean, and Japan, with human T cell lymphoma-leukemia virus (HTLV) associated T cell malignancies, possess HTLV-specific antibodies directed against internal structural components of HTLV, p24 and p19. The prevalence of antibodies to HTLV is greater in family members than in random healthy donors, which supports the infectious nature of HTLV and its association with particular aggressive T cell malignancies. Expression of HTLV p24 and p19 has also been observed in cultured T cells of some healthy relatives, and intact virus particles have been released from cells of one possibly pre-leukemic family member.This publication has 17 references indexed in Scilit:
- Identification of HTLV p19 specific natural human antibodies by competition with monoclonal antibodyVirology, 1982
- The human type‐C retrovirus, HTLV, in blacks from the Caribbean region, and relationship to adult T‐cell leukemia/lymphomaInternational Journal of Cancer, 1982
- Human T-cell leukemia-lymphoma virus (HTLV) is in T but not B lymphocytes from a patient with cutaneous T-cell lymphoma.Proceedings of the National Academy of Sciences, 1982
- Asymptomatic type C virus carriers in the family of an adult T-cell leukemia patient.1982
- Natural antibodies to the structural core protein (p24) of the human T-cell leukemia (lymphoma) retrovirus found in sera of leukemia patients in JapanProceedings of the National Academy of Sciences, 1982
- ADULT T-CELL LYMPHOMA-LEUKAEMIA IN BLACKS FROM THE WEST INDIESThe Lancet, 1982
- Natural Antibodies to Human Retrovirus HTLV in a Cluster of Japanese Patients with Adult T Cell LeukemiaScience, 1982
- Characterization and distribution of nucleic acid sequences of a novel type C retrovirus isolated from neoplastic human T lymphocytes.Proceedings of the National Academy of Sciences, 1981
- Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphomaProceedings of the National Academy of Sciences, 1980
- T-cell lines established from human T-lymphocytic neoplasias by direct response to T-cell growth factor.Proceedings of the National Academy of Sciences, 1980