Two Different in Vitro Growth Patterns for Erythroid Precursors in 18 Patients with Pure Erythrocytosis

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Abstract
Growth patterns of marrow and blood erythroid progenitors were studied in 18 cases of pure erythrocytosis using different doses of erythropoietin. Eight cases demonstrated spontaneous growth of CFU-E [erythroid colony-forming cell] and blood BFU-E [erythroid burst-forming cell] as observed in myeloproliferative disorders, but without an excess of circulating CFU-GM [granulocyte-macropage colony-forming cell]. Three of these patients also had other symptoms of a panmyelopathy. All these cases showed good sensitivity to 32P myelosuppression. Ten cases demonstrated growth patterns of erythroid progenitors similar to those observed in normal subjects, except for an excess of blood BFU-E, which suggests an abnormality of homeostatic regulation. In 5 of these cases, myelosuppression was not effective. A stem cell study could differentiate patients with pure erythrocytosis due to autonomous abnormal stem cell growth from cases due to abnormal regulation factors, and such a discrimination might be useful for the choice of therapy.

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