EFFECT OF TREATMENT WITH DIETHYLSTILBESTROL-POLYESTRADIOL PHOSPHATE OR ESTRAMUSTINE PHOSPHATE (ESTRACYT) ON NATURAL-KILLER CELL-ACTIVITY IN PATIENTS WITH PROSTATIC-CANCER

  • 1 January 1981
    • journal article
    • research article
    • Vol. 18  (6) , 437-439
Abstract
The effect of treatment of patients with prostatic cancer with estramustine phosphate or the combination diethylstilbestrol-polyestradiol phosphate on the natural killer cell activity in peripheral blood was evaluated. Although estramustine phosphate did not affect natural killer cell activity, diethylstilbestrol-polyestradiol phosphate substantially reduced natural killing after a treatment period of 1 wk. The activity was only slightly further lowered after 4 wk of treatment. Possible clinical implications of the difference in susceptibility of natural killer cells to these agents are discussed.