IMMUNOGLOBULIN CONCENTRATIONS IN FIRST-DEGREE RELATIVES OF EPILEPTIC PATIENTS WITH DRUG-INDUCED IgA DEFICIENCY

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Abstract
Serum Ig [immunoglobulin]A, IgG and IgM were studied in the parents and siblings of 16 patients being treated for epilepsy. Five healthy families served as controls. Seven of the patients were low IgA-responders and the rest of the patients showed normal IgA-levels during treatment. None of the parents and siblings studied showed a serum-IgA deficiency, with the exception of 1 mother who was being treated for rheumatoid arthritis with naproxen. Low serum concentrations of IgG and IgM were not found. A significantly increased IgM level was found in 1st-degree relatives of the low IgA-responders, and the sibling of low IgA-responders had significantly raised IgA in their sera.