Development of Lipemia in Rats Following Intravenous Injection of India Ink.

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Abstract
Intravenous injection of commercial India ink in rats caused a significant increase in total fatty acid content of the blood. The effect of a single injection lasted from 2 to 4 hours. The lipemia appeared to be caused by the shellac in the commercial ink. Pelikan Carbon made up in saline and gelatin did not cause lipemia, though it readily saturated the reticular endothelial system. The mechanism by which the shellac induces lipemia is obviously different from that of protamine. India ink does not prevent release of clearing factor (lipoprotein lipase). Heparin injected at peak of the India ink-induced lipemia reduces the lactescence much more than it reduces total fatty acid level.

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