Spontaneous Bone Tumours of Mice

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Abstract
This is an account of the origin and establishment of an inbred strain of mice with a high incidence of spontaneous bone tumours. A description of the Simpson Strain maintained in this laboratory since 1929 has been published elsewhere (Pybus and Miller, 1934) in connection with spontaneous mammary carcinoma, the incidence of which is very high. It was known (Marsh, 1929) that, in addition to mammary, liver and lung tumours, occasional sarcomata occurred in the strain, but it was not until 1933, by which time 3 bone tumours and 2 spindle-cell subcutaneous sarcomata had appeared among the descendants of our original pair of mice, that the possibility of establishing an inbred sarcoma strain presented itself.

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