Detection of mip-like sequences and mip-related proteins within the family Rickettsiaceae
- 1 March 1995
- journal article
- Published by Springer Nature in Current Microbiology
- Vol. 30 (3) , 149-153
- https://doi.org/10.1007/bf00296200
Abstract
The Mip surface protein, a prokaryotic analog of the FK506-binding proteins, enhances the ability of Legionella pneumophila to infect macrophages and protozoa. Using mip-specific probes and low-stringency Southern hybridizations, we have detected DNA sequences homologous to mip within Coxiella burnetii and Rochalimaea quintana. Using specific anti-Mip antisera and immunoblot analysis, we also detected Mip-related proteins within these bacteria as well as within Rickettsia and Ehrlichia species. These data suggest that Mip-related proteins have broad significance for host-parasite interactions. However, they also indicate that care must be exercised when using mip probes or anti-Mip antibodies for the detection of Legionella organisms in water or clinical samples.Keywords
This publication has 24 references indexed in Scilit:
- Analysis in Neisseria meningitidis and other Neisseria species of genes homologous to the FKBP immunophilin familyMolecular Microbiology, 1993
- Chlamydia trachomatis Mip‐like protein has peptidylprolyl cis/trans isomerase activity that is inhibited by FK506 and rapamycin and is implicated in initiation of chlamydial infectionMolecular Microbiology, 1993
- Chlamydia trachomatis Mip‐like proteinMolecular Microbiology, 1992
- Legionella pneumophila mip gene potentiates intracellular infection of protozoa and human macrophages.Proceedings of the National Academy of Sciences, 1992
- Mip protein of Legionella pneumophila exhibits peptidyl‐prolyl‐cis/trans isomerase (PPIase) activityMolecular Microbiology, 1992
- Isolation and sequence of an FK506-binding protein from N. crassa which catalyses protein foldingNature, 1990
- Molecular cloning and overexpression of the human FK506-binding protein FKBPNature, 1990
- A Mutation in the mip Gene Results in an Attenuation of Legionella pneumophila VirulenceThe Journal of Infectious Diseases, 1990
- Nucleotide sequence of a regulatory region controlling alginate synthesis in Pseudomonas aeruginosa: characterization of the algR2 geneGene, 1989
- The Perils of PromiscuityThe Journal of Infectious Diseases, 1988