Brief Communication : Regression of Autochthonous Moloney Sarcoma Virus-Induced Tumors in Mice Treated With Polyriboinosinic Acid-Polyribocytidylic Acid 2
- 1 February 1974
- journal article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 52 (2) , 591-594
- https://doi.org/10.1093/jnci/52.2.591
Abstract
NMRI mice infected neonatally with the Moloney strain of murine sarcoma virus (M-MSV) developed progressively growing tumors. These tumors did not regress and invariably killed the host. However, if these animals were treated repeatedly with polyriboinosinicpolyribocytidylic acid (poly I :C) on alternate days (from 40 to 60 days after M-MSV inoculation), 75% of the established tumors regressed. The exact mechanism of this marked stimulatory effect of poly I:C on tumor regression is not known.Keywords
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