Antiarrhythmic Action of N, N-Bis (Phenylcarbamoylmethyl) Dimethyl Ammonium Chloride (QX-572) in Cat and Dog

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Abstract
Ventricular arrhythmias were produced in the cat by the: inhalation of halopropane; inhalation of halopropane and CO2; injection of norepinephrine during halopropane inhalation; inhalation of cyclopropane and CO2; injection of norepinephrine during cyclopropane inhalation. Conversion of these arrhythmias to normal sinus rhythm was accomplished by the intravenous administration of 2-10 mg/kg of QX-572, a lidocaine derivative. This agent often produced a fall in blood pressure of 10-20% and a decrease in heart rate of 10-15%. In the dog ventricular arrhythmias produced by the inhalation of halopropane and CO2 were abolished by 2-8 mg/kg of QX-572. Blood pressure decreased 20-40% while heart rate increased 20-35%. Preliminary studies suggest that QX-572 is also an effective antiarrhythmic agent in man.

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