Differentiation of neuroblastoma cells induced in culture by 6‐thioguanine

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Abstract
In addition to cell death, 6‐thioguanine (TG) and 6‐mercaptopurine induced neurite formation in mouse neuroblastoma cell culture, whereas 2‐aminopurine had no effect on growth or morphology. 6‐TG was much more potent in causing morphological differentiation than any other agents used in this study. It increased the levels of catechol‐o‐methyltransferase and choline acetyltransferase, but had no significant effect on the tyrosine hydroxylase (TH) activity. 5‐bromodeoxyuridine increased the levels of all three enzymes. 6‐TG produced cell death with very little neurite formation in human neuroblastoma cell culture.