Selective aromatization of the A ring of steroids through demethylation by an electrophilic ruthenium fragment

1 January 1991

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications

No. 24,p. 1739-1741
https://doi.org/10.1039/c39910001739

Abstract

The reaction of ‘(C₅Me₅)Ru⁺’, produced by the protonation of [(C₅Me₅)RuOMe]₂ by CF₃SO₃H, with various steroids leads to selective aromatization of the A ring via demethylation of the 19 methyl group and/or dehydration and/or dehydrogenation reactions.

Keywords

SELECTIVE AROMATIZATION
STEROIDS
DEHYDRATION
RUTHENIUM
PROTONATION
CF3SO3H
ELECTROPHILIC
RUOME

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