Induction of hepatocellular carcinoma and highly metastatic squamous cell carcinomas in the forestomach of mice by feeding 2-amino-3, 4-dimethylimidazo[4, 5-f]quinoline

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Abstract
2-Amino-3, 4-dimethylimidazo[4, 5- f ]quinoline (MelQ), a potent mutagen which was Isolated from grilled sardines, was tested for carcinogenicity in CDF1 mice. Mice were given diet containing 0.04 or 0.01% MelQ for 91 weeks. The incidences of liver tumors (hepatocellular carcinomas and hepatocellular adenomas) in female mice given 0.04 and 0.01% MelQ were significantly higher than those in controls. The incidences of forestomach tumors (squamous cell carcinomas and papil-lomas) were also significantly higher in both sexes of mice given MelQ. About 40% of the squamous cell carcinomas that developed in mice given diet containing 0.04% MelQ meta-stasized to the liver.

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