Red-Cell Sodium–Lithium Countertransport in Sons of Normotensive and Hypertensive Parents: A Follow-up Study

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Abstract
To the Editor: There has been recent interest in the possibility that studies of cation transport in blood cells might reveal the presence of alterations that would serve as genetic markers for essential hypertension. One such pathway, sodium–lithium countertransport, has been found by some, but not all, investigators to be elevated in patients with essential hypertension or their relatives when compared with that of normotensive controls.1 Dorus et al.2 have shown that the rate is influenced by genetic factors. Duhm and Becker,3 in studies over a period exceeding two red-cell life spans in four donors, concluded that this pathway appeared . . .

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