Staphylococcal Immunity: Production of Staphylococcal Hemagglutinins in Rabbits Receiving Staphylococcal Vaccine.

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Abstract
1. Injections of 2 staphylococcal bacterial cell vaccines resulted in prompt antibody response in normal adult rabbits which could be detected by a simple hemagglutination test. Maximal antibody titers were reached in 30 to 40 days with weekly injections. The intravenous route yielded maximal antibody production. 2. Variations in concentration of red blood cells or antigen employed in sensitizing red cells produced marked alterations in the hemagglutinating end point when tested against standard high titer sera. Careful standardization was thus required to obtain reproducible results. 3. Sensitizing antigen prepared from various heterologous coagulase positive staphylococci of different phage types yielded cross reactions at lower dilutions against sera obtained from vaccinated animals. Antigen prepared from a single coagulase negative strain cross reacted with high titer serum only at low dilutions.

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