Double‐blind comparison of meptazinol and pethidine in labour

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Abstract
The analgesic efficacy and safety of i.m. meptazinol and pethidine in the 1st stage of labor were compared in a randomized double-blind trial in 358 patients. Pain relief was measured on a verbal rating scale, maternal side effects were recorded and neonatal outcome assessed in the first 24 h. Pain relief during the 1st h after injection was significantly greater in the meptazinol than in the pethidine group at 45 and 60 min. There was no difference between the treatments, and the duration of action was approximately the same. Patients (28%) experienced side effects after meptazinol compared with patients (35%) after pethidine. The commonest were nausea and vomiting with a similar incidence in both groups. Most of the neonatal observations revealed no difference between the 2 drugs, but significantly more babies whose mothers had received meptazinol had an Apgar score of .gtoreq. 8 at 1 min after birth.

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