Use of an Animal Model in Studies of Bacterial Corneal Infection

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Abstract
Bacterial corneal infection (bacterial keratitis) is the most common cause of suppurative corneal ulceration ( Wilhelmus 1996 ). Despite continual improvement of available medical therapies, permanent corneal opacity frequently results. Occasionally the infection will be so destructive that a transplant is required. Approximately 0.5 to 1.0% of US cases of corneal infection require surgery. More seriously, bacterial keratitis is a major cause of vision loss in developing countries (trachoma and xerophthalmia being the most common causes).