Inflammation is a feature of the disease process in early knee joint osteoarthritis

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Abstract
Sir, Traditionally osteoarthritis (OA) has been considered a process involving a disturbance of the normal balance between degradation and repair in the articular cartilage and subchondral bone. In contrast to rheumatoid arthritis where inflammation, both local and systemic, is a key feature, OA is considered a primarily non‐inflammatory condition. The clinical signs of low‐grade inflammation that are seen in some patients, representing later stages of the process, have been thought to reflect secondary events in the joint. This view has been questioned and in a recent review arguments in favour of inflammation being of major importance in OA pathophysiology were presented [1]. In support, in established OA, low‐level increases in serum C‐reactive protein (CRP) have been reported [2, 3].

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