Synthetic Lethal Interactions Identify Phenotypic “Interologs” of the Spindle Assembly Checkpoint Components
- 1 December 2007
- journal article
- research article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 177 (4) , 2525-2530
- https://doi.org/10.1534/genetics.107.080408
Abstract
Here, we report genetic interactions with mdf-1(gk2)/MAD1 in Caenorhabditis elegans. Nine are evolutionarily conserved or phenotypic “interologs” and two are novel enhancers, hcp-1 and bub-3. We show that HCP-1 and HCP-2, the two CENP-F-related proteins, recently implicated in the spindle assembly checkpoint (SAC) function, do not have identical functions, since hcp-1(RNAi), but not hcp-2(RNAi), enhances the lethality of the SAC mutants.This publication has 45 references indexed in Scilit:
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