Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism
- 20 December 2006
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry
- Vol. 15 (5) , 2156-2166
- https://doi.org/10.1016/j.bmc.2006.12.026
Abstract
No abstract availableKeywords
This publication has 36 references indexed in Scilit:
- Pregnane X receptor (PXR) activation: A mechanism for neuroprotection in a mouse model of Niemann–Pick C diseaseProceedings of the National Academy of Sciences, 2006
- Human PXR Forms a Tryptophan Zipper-Mediated HomodimerBiochemistry, 2006
- LXRs regulate the balance between fat storage and oxidationCell Metabolism, 2005
- Crystal Structure of the Human Liver X Receptor β Ligand-binding Domain in Complex with a Synthetic AgonistJournal of Molecular Biology, 2003
- 2.1 Å Crystal Structure of Human PXR in Complex with the St. John's Wort Compound Hyperforin,Biochemistry, 2003
- SXR, a novel steroid and xenobioticsensing nuclear receptorGenes & Development, 1998
- The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.Journal of Clinical Investigation, 1998
- Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRαCell, 1998
- An oxysterol signalling pathway mediated by the nuclear receptor LXRαNature, 1996
- Improved methods for building protein models in electron density maps and the location of errors in these modelsActa Crystallographica Section A Foundations of Crystallography, 1991