Synthesis of diaminodideoxyalditol analogs of cisplatin as antitumor agents
- 1 June 1993
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 71 (6) , 880-885
- https://doi.org/10.1139/v93-117
Abstract
Acyclic vicinal polyol complexes related to cisplatin were synthesized from D-mannitol by stereocontrolled manipulation of the hydroxy groups. Controlled cleavage of a 3,4-diazido hexitol gave the corresponding D-threitol and D-xylitol analogs, which were converted to their diamino platinum complexes. The antitumor activity of these compounds is reported.Keywords
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