High intensity knee extensor training, in patients with chronic heart failure: Major skeletal muscle improvement
Open Access
- 1 July 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in European Heart Journal
- Vol. 17 (7) , 1048-1055
- https://doi.org/10.1093/oxfordjournals.eurheartj.a015001
Abstract
Skeletal muscle adaptations to high intensity knee extensor strength and/or endurance training in patients with chronic heart failure were investigated. Eleven patients with chronic heart failure were randomized into two groups and exercised the m. quadriceps femoris 3 days/week for 8 weeks. After training, the maximal exercise intensity tolerated on the ergometer cycle was raised from 99 (32) to 114 (40) watts (W, PPPPP<0·05). The oxidative enzyme activity in m. vastus lateralis was significantly raised above 50% after endurance training, whereas glycolytic enzyme activity was unaltered. The peripheral skeletal musculature in patients with chronic heart failure adapts fairly quickly to high intensity knee extensor training. This results in a marked rise in local, and a small rise in total work capacity, indicating maintained plasticity of skeletal muscle in chronic heart failure patients.Keywords
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