The effects of chlorpromazine on the course of discrimination-reversal learning in the rat.

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Abstract
In a Lashley jumping apparatus a series of discrimination reversals was given to rats receiving chlorpromazine injections and to a control group. For half of each group the problem was a visual discrimination; for the remainder a spatial problem was used. Some of the controls, but none of the drug group, adopted rigid position fixations on the visual problem. In both problems, the drug group reached a lower error-per-reversal asymptote. The possibility that the drug acts upon the disrupting effect of punishment is discussed. (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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