Preliminary Evaluation of VM-26 A New Epipodophyllotoxin Derivative, in the Treatment of Urogenital Tumours
- 1 January 1975
- journal article
- clinical trial
- Published by Elsevier in European Urology
- Vol. 1 (1) , 53-56
- https://doi.org/10.1159/000455576
Abstract
VM-26, a podophyllin derivative, is cytotoxic in vitro against cell cultures of bladder tumours. lntravenous therapy of vesical carcinoma produccs only occasional responses, One total regression was observed in our series. Intravesical instillations are more effectivc. Topical treatment of papillomatosis led to total or partial regression in one half of cases, A significant reduction of recurrence rate following transurethral surgery was obtained in patients treated intravesically with VM-26 at weekly intervals.Keywords
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