Effect of Heparin on the Decrease in Blood Coagulation Factor Activity Associated with Experimental Endotoxemia
- 1 March 1967
- journal article
- research article
- Published by Wolters Kluwer Health in Annals of Surgery
- Vol. 165 (3) , 351-356
- https://doi.org/10.1097/00000658-196703000-00003
Abstract
Preheparinized and nonheparinized mongrel dogs were given endotoxin, and clotting factor activity was studied using the one-stage prothrombin time and partial thromboplastin time. Loss of clotting factor activity in hepartaized animals was largely prevented, whereas control animals lost significant amounts of clotting factor activity. Preheparinization did not affect mortality. The possible mechanisms by which heparin may prevent loss of clotting factor activity are discussed.This publication has 13 references indexed in Scilit:
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