New Tests for Hepatitis B Virus

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Abstract
Recent developments in the understanding of hepatitis B may result in the introduction of new screening and diagnostic tests, adding to the bewildering array of technics that are currently available for the detection of hepatitis B antigen (Australia antigen) and its homologous antibody. These developments stem from two discoveries made in England with the aid of the electron microscope. The description by Dane et al.1 of distinct virus-like, double-shelled, 42-nm spheroidal particles in the serum of some patients with acute illness associated with hepatitis B antigen was followed by the finding, by immune electron microscopy, of a second antigen–antibody system . . .