HEPARIN TREATMENT OF DEEP-VEIN THROMBOSIS - EFFECTS AND COMPLICATIONS AFTER CONTINUOUS OR INTERMITTENT HEPARIN ADMINISTRATION

  • 1 January 1981
    • journal article
    • research article
    • Vol. 210  (5) , 357-361
Abstract
Patients (28) with the diagnosis of deep vein thrombosis (DVT) were subjected to a prospective, randomized study comparing continuous and intermittent heparin treatment, utilizing the same doses and duration of therapy. The effect on pain (estimated with a scoring system) and the antithrombotic effect (assessed by the inhibition of 125I-fibrinogen accretion), followed for 1 wk, were unrelated. Pulmonary embolism was scored and studied from lung perfusion scans and chest X-rays. A high frequency was found in both groups. The therapeutic efficacy and side-effects did not differ between the 2 treatment groups. Bleeding, preferentially from vein puncture (post-phlebography), was more common in women, while a heparin-induced elevation of serum aminotransferases (S-ALAT [serum alanine aminotransferase] and S-ASAT [serum aspartate aminotransferase]) in 2/3 of the patients was not related to age, sex or bleeding complications.