Differences in Thermostability of Antigenically Related Strains of Poliomyelitis Virus.

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Abstract
Three rodent adapted strains of poliomyelitis virus, all belonging to the same immunologic type, differed in their thermostability; these were, in decreasing order of resistance, Y-SK, MEF1, and Lansing. The differences between these strains became evident only when they were suspended in cream or ice cream before being heated. All 3 strains suspended in water were inactivated by heating at 71.1[degree]C for 15 sec. When heated in cream the viruses withstood 79.5[degree]C for 15 sec. and in ice cream they withstood 82.2[degree]C for 25 sec., with Y-SK resisting inactivation to the greatest extent.