Membranoproliferative Glomerulonephritis in a Patient with Hairy-Cell Leukemia Treated with Alpha-II Interferon

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Abstract
To the Editor: There are a number of case reports of patients with hairy-cell leukemia in whom the nephrotic syndrome developed during the course of the illness.1 , 2 Previously described histopathological processes include IgA nephropathy,1 amyloidosis,2 immune-mediated glomerulonephritis with cryoglobulinemia,3 and vasculitis.4 In addition, the nephrotic syndrome has developed in patients with a variety of disorders who received alpha-II interferon.5 This has been associated with minimal-change nephropathy with interstitial nephritis.6 We describe a patient with hairy-cell leukemia in whom the nephrotic syndrome was secondary to membranoproliferative glomerulonephritis and developed after treatment with alpha-II interferon for one year.The patient was a . . .