MEDULLIADRENAL SECRETION AND CARBOHYDRATE METABOLISM

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Abstract
The suppression of adrenin secretion, by ablation of the adrenal medulla or by denervation in cats, resulted in a 4-10 fold permanent increase in sensitivity to insulin. Injection of ergotamine to depress the sympathetic nervous system slightly accentuated the hypersensitivity, while very small amounts of adrenalin afforded protection against insulin shock. Medulliadrenal inactivated animals showed no increase in blood sugar immediately following convulsions, and no ability to recover, as did un-operated controls. Hepatic and muscle glycogen was normal in amount. The results indicate that adreno-medullary secretion becomes increasingly important during the progress of an emergency condition such as insulin hypoglycemia, and that in the absence of this secretion the hepatic glycogen reserves have a much restricted availability to the muscular and other tissues.

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