Focal Antibody Production by Transferred Spleen Cells in Irradiated Mice
- 26 August 1965
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 149 (3687) , 998-1000
- https://doi.org/10.1126/science.149.3687.998
Abstract
Lethally irradiated mice were injected with small numbers of normal spleen cells and then immunized with sheep erythrocytes. Antibody activity was found in their spleens in localized areas whose number corresponded to the number of spleen cells injected. When sheep and pig erythrocytes were injected together, antibody against each was found in separate areas. Each area may consist of the progeny of a single precursor cell, restricted to forming a single antibody.This publication has 7 references indexed in Scilit:
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- PROTECTION OF X-IRRADIATED MICE BY “CLONED” HAEMOPOIETIC CELLS1Transplantation, 1965
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- Plaque Formation in Agar by Single Antibody-Producing CellsScience, 1963
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- A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow CellsRadiation Research, 1961