DIRECT CULTIVATION OF BACTERIUM TULARENSE FROM HUMAN BLOOD DRAWN DURING LIFE AND AT AUTOPSY
- 1 October 1941
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1908)
- Vol. 68 (4) , 747-762
- https://doi.org/10.1001/archinte.1941.00200100086007
Abstract
THE OCCURRENCE OF BACTEREMIA The concept of invasion of the blood stream in tularemia is embodied in the name given to the disease by Francis,1who wrote: "The name tularemia is based upon the specific name Bacterium tularense, plus -aemia, from the Greek, and has reference to the presence of this bacterium in the blood." In early investigations direct proof of bacteremia was furnished by animal inoculation. Blood from a patient with "deer-fly fever" who ultimately recovered was injected into guinea pigs by Francis1(case 3) and was found to be infectious. Simpson2similarly recovered the organism in 1 nonfatal case (XI) and also in a rapidly fatal case in which the blood was taken on the day before death. Such observations have been amply confirmed by others who have demonstrated by guinea pig inoculation the presence of B. tularense in the blood in fatal cases, bothThis publication has 0 references indexed in Scilit: