Reversible cholestasis with bile duct injury following azathioprine therapy. A case report

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Abstract
ABSTRACT— A 67‐year‐old patient, with primary polymyositis and without previous evidence of liver disease, developed clinical and biochemical features of severe cholestasis 3 months after initiation of azathioprine therapy. Liver biopsy showed cholestasis with both cytological and architectural alterations of interlobular bile ducts. Azathioprine withdrawal resulted after 7 weeks in the resolution of clinical and biochemical abnormalities. It is believed that this is the first reported case of reversible azathioprine‐induced cholestasis associated with histological evidence of bile duct injury.