Amphidinolide Y, a Novel 17-Membered Macrolide from Dinoflagellate Amphidinium sp.: Plausible Biogenetic Precursor of Amphidinolide X
- 23 October 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 68 (23) , 9109-9112
- https://doi.org/10.1021/jo035278z
Abstract
A novel cytotoxic 17-membered macrolide, amphidinolide Y (1), has been isolated from a marine dinoflagellate Amphidinium sp., and it was elucidated to exist as a 9:1 equilibrium mixture of 6-keto- and 6(9)-hemiacetal forms (1a and 1b, respectively) on the basis of 2D NMR data and chemical means. The feeding experiments with 13C-labeled acetates suggested that amphidinolide Y (1) may be a biogenetic precursor of 16-membered macrodiolide, amphidinolide X (2).Keywords
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