Usnic acid derivatives as potential antineoplastic agents
- 1 November 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 22 (11) , 1380-1384
- https://doi.org/10.1021/jm00197a019
Abstract
Usnic acid, a lichen [Cladonia alpestris and Ramalina reticulata] antibiotic, showed low-level activity in the Lewis [mouse] lung carcinoma test system. In an effort to produce new agents of potential use in the treatment of lung cancer, derivatives of the natural product were synthesized and evaluated with a cytotoxicity assay. Structure-activity analysis of the cytotoxicity data indicated the importance of the lipophilicity and the .beta.-triketone moiety of usnic acid on cytotoxicity. No significant increases in survival of mice over controls were shown by any of the synthetic compounds in the [mouse] P388 leukemia or the Lewis lung carcinoma test systems.This publication has 3 references indexed in Scilit:
- Synthesis and antitumor activity of dihydro-5-azacytidine, a hydrolytically stable analog of 5-azacytidineJournal of Medicinal Chemistry, 1977
- Studies in the usnic acid series. I. The condensation of (+)-usnic acid with aliphatic and aromatic aminesCanadian Journal of Chemistry, 1976
- Method of Isolation of Usnic Acid from Ramalina reticulataJournal of the American Chemical Society, 1950