UPDATE: PH Domains--A Universal Membrane Adapter
- 28 March 1997
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 275 (5308) , 1899
- https://doi.org/10.1126/science.275.5308.1899
Abstract
The enzyme PI 3-kinase seems to mediate extraordinarily diverse cellular responses to growth factors. In his Update Perspective, Hemmings offers an explanation by outlining the evidence for a common target of the phospholipid signaling molecules generated by PI 3-kinase—the pleckstrin homology (PH) domains located on at least 100 cellular proteins, which could mediate the diverse responses of cells. On p. 1927 of this issue, Klarlund et al . report the isolation of one of these PH domain-containing proteins, GRP1.Keywords
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