Histopathological Changes in the Lungs in Patients with Malignant Tumors Treated with Bleomycin

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Abstract
Histopathological changes in the lungs of 7 patients with malignant tumors treated with Bleomycin are characterized by hyperplasia and endoalveolar migration of type II pneumocytes and macrophages, hyaline membrane formation and the appearance of newly formed reticular and collagen fibers within the alveolar septa and hyperplasia of muscular fibers of respiratory bronchioli. These findings are consistent with the diagnosis of interstitial pneumonia, the morphologic pattern of which is often complicated by either pre-existing pulmonary damage or supervening lesions. The direct or indirect role of bleomycin in the etiology and pathogenesis of the pulmonary disease as described above seems to be ascertained, since the pathological findings are in keeping with clinical and radiological data.