Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras.
Open Access
- 1 January 1980
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 151 (1) , 246-251
- https://doi.org/10.1084/jem.151.1.246
Abstract
The mechanism of restriction of T-cell specificity by the genotype of the thymus in allogeneic and semiallogeneic chimeras was investigated. Lack of induction of delayed-type hypersensitivity (DTH) directed against antigen in association with the nonthymic parental haplotype in naive cells adoptively transferred into chimeras suggests the existence of an in vivo suppressive mechanism. However, it was not possible to suppress the expression of DTH in sensitized cells transferred into chimeras, or to transfer this suppression to normal naive recipients.This publication has 17 references indexed in Scilit:
- Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H‐2‐Restriction‐Specificity and in H‐2 Linked Ir Gene ControlImmunological Reviews, 1978
- H-2 antigens of the thymus determinelymphocyte specificityThe Journal of Experimental Medicine, 1978
- Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.Proceedings of the National Academy of Sciences, 1978
- T cells specific for hapten-modified self are precommitted for self major histocompatibility complex antigens before encounter with the hapten.The Journal of Experimental Medicine, 1978
- A Dual Recognition Model for Cytotoxic T Cells Based on Thymic Selection of Precursors with Low Affinity for Self H-2 AntigensScandinavian Journal of Immunology, 1978
- Expression and Function of Idiotypes on LymphocytesPublished by Elsevier ,1978
- The generation of killer cells to trinitrophenyl-modified allogeneic targets by lymphocyte populations negatively selected to strong alloantigens.The Journal of Experimental Medicine, 1977
- Nature of the antigenic complex recognized by T lymphocytes: specific sensitization by antigens associated with allogeneic macrophages.Proceedings of the National Academy of Sciences, 1977
- Two Different VH Gene Products Make Up the T‐Cell ReceptorsScandinavian Journal of Immunology, 1976
- The Function and Interrelationships of T-Cell Receptors, Ir Genes and Other Histocompatibility Gene ProductsImmunological Reviews, 1975