Effects of serotonin, carbamylcholine, and ascorbic acid on leukocyte cyclic GMP and chemotaxis.
Open Access
- 1 November 1975
- journal article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 67 (2) , 480-484
- https://doi.org/10.1083/jcb.67.2.480
Abstract
Serotonin, ascorbic acid, and carbamylcholine enhanced the chemotactic responsiveness of human monocytes to endotoxin-treated serum. These agents caused significant accumulation of cyclic GMP in monocytes. PMN leukocyte chemotaxis was also enhanced by these agents although significant increases in cyclic GMP were not demonstrated.Keywords
This publication has 10 references indexed in Scilit:
- Guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate content of human umbilical artery.Journal of Clinical Investigation, 1975
- The effect of serotonin (5-hydroxytryptamine) and derivatives on guanosine 3',5'-monophosphate in human monocytes.Journal of Clinical Investigation, 1975
- THE REGULATORY ROLE OF DIVALENT CATIONS IN HUMAN GRANULOCYTE CHEMOTAXISThe Journal of cell biology, 1974
- Enhancement of Random Migration and Chemotactic Response of Human Leukocytes by Ascorbic AcidJournal of Clinical Investigation, 1974
- Cyclic GMP and Cell MovementNature, 1973
- Granulocyte Chemotaxis: An Improved in Vitro Assay Employing 51Cr-Labeled GranulocytesThe Journal of Immunology, 1973
- The effect of Ca2+ and Mg2+ on the chemotactic responsiveness and spontaneous motility of rabbit polymorphonuclear leukocytes.1972
- Human Mononuclear Leukocyte Chemotaxis: A Quantitative Assay for Humoral and Cellular Chemotactic FactorsThe Journal of Immunology, 1972
- Defective granulocyte chemotaxis in the Chediak-Higashi syndromeJournal of Clinical Investigation, 1971
- Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.1968