Pharmacological Studies of Perillae Herba. I. Neuropharmacological Action of Water Extract and Perillaldehyde

Open Access
Publisher Website
Google Scholar
Abstract
Neuropharmacological actions of the water extract of Perillae Herba [Perilla frutescens var. acuta] and perillaldehyde which is one of the main components of the essential oil of this crude drug, were examined. In ddY strain mice, a dose of 4 g/kg, p.o. (per os) of the water extract and 100 mg/kg, p.o. of perillaldehyde exerted a significant prolongation of sleeping time induced by the administration of hexobarbital Na but did not show any effects on the body temperature and the rotating rod performance. On the laryngeal reflex in cats, the water extract and perillaldehyde exerted an inhibitory effect, and such inhibitory effects were observed on the excitable membranes by using an isolated snail neuron and frog sciatic nerve fibers. With the continuous administration of the water extract or perillaldehyde, only the water extract showed a depressive effect on the spontaneous locomotor activity in Fischer strain rats. The water extract of Perillae Herba and perillaldehyde may have a depressive action on the CNS.

This publication has 1 reference indexed in Scilit: