Effect of Synthetic Lysine Polypeptides on Rabbit Blood Coagulation.
- 1 February 1953
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 82 (2) , 231-234
- https://doi.org/10.3181/00379727-82-20075
Abstract
Synthetic polypeptides were investigated for their effects on rabbit blood coagulation in vitro and in vivo. The basic L-lysine polypeptides prolonged whole-blood clotting time, increased prothrombin time and neutralized the effect of heparin. A synthetic L-glutamic acid polypeptide inhibited these effects of polylysine and protamine. In mice, guinea pigs, and rabbits the lysine polypeptides produced anaphylactoid symptoms which closely resembled those of protamine toxicity. A mechanism involving a combination of the basic polypeptides with acidic protein surfaces or with heparin is discussed to explain some of these re suits.Keywords
This publication has 2 references indexed in Scilit:
- SYNTHESIS AND ENZYMATIC HYDROLYSIS OF GLUTAMIC ACID POLYPEPTIDESJournal of Biological Chemistry, 1952
- The action of some water-soluble poly-α-amino-acids on blood clottingBiochemical Journal, 1951