Epiphyseal Growth Zones in Acute Lathyrism. Determinations of Water, Hydroxyproline and Mucopolysaccharides

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Abstract
Summary Biochemical analyses of growth zones of young rabbits suffering from acute lathyrism showed that an increase in water and hydroxyproline in epiphyseal cartilage and a decrease of hydroxyproline in meta-physeal spongiosa constitute the initial alterations. In the more pronounced lathyritic state, hexosamine and uronic acid decreased in cartilage and increased in bone. Acid mucopoly-saccharides may play a regulating part in the process of endochondral ossification.