Synthesis and biophysical studies of short oligodeoxynudeotides with novel modifications: a possible approach to the problem of mixed base oligodeoxynudeotide synthesis
- 1 January 1984
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 12 (19) , 7435-7453
- https://doi.org/10.1093/nar/12.19.7435
Abstract
The syntheses of 1,2-dideoxy-D-ribofuranose and 1,2-dideoxy-1-phenyl-beta-D-ribofuranose are described. Oligodeoxynucleotides containing these analogues have been synthesised and hybridized to their complementary strands. Hypochromicity studies have shown that these duplices are less stable than either the totally complementary duplex or those containing A.C and G.T mismatches.Keywords
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